产品概述
ATM (9F7) Mouse Monoclonal Antibody
Mouse Monoclonal Antibody
Mouse
IHC-P
Human,Rat,Mouse
产品性能
Unconjugated
Unmodified
IgG1
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Purification
免疫原
ATM
ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
472
Q13315
产品应用
IHC: 1:50-1:100
-
研究背景
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.
研究领域
Epigenetics and Nuclear Signaling
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