产品概述
beta Arrestin 1 (6A1) Mouse Monoclonal Antibody
Mouse Monoclonal Antibody
Mouse
WB
Human
产品性能
Unconjugated
Unmodified
IgG2b
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Purification
免疫原
ARRB1
ARB1; ARR1; ARRB1; ARRB1_HUMAN; Arrestin 2; Arrestin beta 1; Arrestin beta-1; Beta-arrestin-1.
408
P49407
产品应用
WB: 1:500-1:1000
Calculated MW: 47 kDa; Observed MW: 51 kDa
研究背景
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
研究领域
Signal Transduction
武汉恩玑生命科技有限公司
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