产品概述
HDAC3 (3G3) Mouse Monoclonal Antibody
Mouse Monoclonal Antibody
Mouse
WB
Human,Mouse,Rat
产品性能
Unconjugated
Unmodified
IgG1
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Purification
免疫原
HDAC3
HDAC3; Histone deacetylase 3; HD3; RPD3-2; SMAP45
8841
O15379
产品应用
WB: 1:500-1:1000
Calculated MW: 49 kDa; Observed MW: 49 kDa
研究背景
HDAC3 is a nuclear and cytoplasmic protein that deacetylates both histone (H2A, H3, H4) and non-histone substrates (RelA, SRY, p53, MEF2, PCAF and p300/CBP). HDAC3 deacetylase activity is stimulated by interactions with the N-CoR and SMRT co-repressor proteins. Together, these three proteins form a functional complex that represses transcription associated with nuclear hormone receptors and other transcription factors, including Rev-Erb, COUP-TF, DAX1, MAD and Pit-1.
研究领域
Epigenetics and Nuclear Signaling
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