产品概述
CRK (3H7) Mouse Monoclonal Antibody
Mouse Monoclonal Antibody
Mouse
WB
Human
产品性能
Unconjugated
Unmodified
IgG2b
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Purification
免疫原
CRK
Adapter molecule crk; avian sarcoma virus CT10 (v-crk) oncogene homolog; CRK; CRKII; Proto-oncogene c-Crk
1398
P46108
产品应用
WB: 1:500-1:1000
Calculated MW: 34 kDa; Observed MW: 34 kDa
研究背景
The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
研究领域
Neuroscience
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