产品概述
Bax (2B12) Mouse Monoclonal Antibody
Mouse Monoclonal Antibody
Mouse
WB
Human,Monkey
产品性能
Unconjugated
Unmodified
IgG2a
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Purification
免疫原
BAX
Apoptosis regulator BAX; BAX; Bcl-2-like protein 4; BCL2-associated X protein; Bcl2-L-4; BCL2L4
581
Q07812
产品应用
WB: 1:500-1:1000
Calculated MW: 21 kDa; Observed MW: 21 kDa
研究背景
Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9 and initiation of the caspase activation pathway for apoptosis.
研究领域
Cell Biology
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