产品概述
Argonaute 2 Rabbit Monoclonal Antibody
Rabbit Monoclonal antibody
Rabbit
WB,ICC/IF,IP
Human
产品性能
Unconjugated
Unmodified
IgG
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Affinity Purification
免疫原
AGO2
Ago 2; Argonaute 2; dAgo2; eIF2C 2; hAgo2; PPD
27161
Q9UKV8
产品应用
WB: 1:500-1:1000 IF: 1:50-1:200 IP: 1:20
Calculated MW: 97 kDa; Observed MW: 97 kDa
研究背景
Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). Can also upregulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and upregulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.
研究领域
Epigenetics and Nuclear Signaling
武汉恩玑生命科技有限公司
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