产品概述
Cyclin E2 Rabbit Monoclonal Antibody
Rabbit Monoclonal antibody
Rabbit
WB,IHC-F,IHC-P,ICC/IF
Human
产品性能
Unconjugated
Unmodified
IgG
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Affinity Purification
免疫原
CCNE2
CCNE2; G1/S-specific cyclin-E2
9134
O96020
产品应用
WB: 1:500-1:1000 IHC: 1:50-1:100 IF: 1:50-1:200
Calculated MW: 47 kDa; Observed MW: 47 kDa
研究背景
The human Cyclin E2 gene encodes a 404 amino acid protein that is most closely related to Cyclin E. Cyclin E2 mRNA levels peaks at the G1 / S transition. Cyclin E2 associates with Cdk2 in a functional kinase complex that is inhibited by both p27 (Kip1) and p21 (Cip1). Cyclin E2 / Cdk2 phosphorylates histone H1 in vitro. G1 cyclin E controls the initiation of DNA synthesis by activating CDK2. Abnormally high levels of cyclin E expression have frequently been observed in human cancers.
研究领域
Cell Biology
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