产品概述
TRIM23 Rabbit Monoclonal Antibody
Rabbit Monoclonal antibody
Rabbit
WB
Human,Mouse,Rat
产品性能
Unconjugated
Unmodified
IgG
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Affinity Purification
免疫原
TRIM23
ARD1; ARFD1; RNF46
373
P36406
产品应用
WB: 1:500-1:1000
Calculated MW: 64 kDa; Observed MW: 64 kDa
研究背景
Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090).
研究领域
Signal Transduction
武汉恩玑生命科技有限公司
联系商家时请提及chemicalbook,有助于交易顺利完成!
在线客服