产品概述
NMDAR2A Rabbit Monoclonal Antibody
Rabbit Monoclonal antibody
Rabbit
WB
Mouse,Rat
产品性能
Unconjugated
Unmodified
IgG
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Affinity Purification
免疫原
Grin2A
NR2A; GluN2A; NMDAR2A; GluRepsilon1
14811
P35436
产品应用
WB: 1:500-1:1000
Calculated MW: 165 kDa; Observed MW: 165 kDa
研究背景
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+. Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kinetics than channels formed by GRIN1 and GRIN2B . Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning.
研究领域
Neuroscience
武汉恩玑生命科技有限公司
联系商家时请提及chemicalbook,有助于交易顺利完成!
在线客服