产品概述
SHC Rabbit Monoclonal Antibody
Rabbit Monoclonal antibody
Rabbit
WB,IHC-F,IHC-P
Human, Mouse, Rat
产品性能
Unconjugated
Unmodified
IgG
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Affinity Purification
免疫原
SHC1
SHC1; SHC; SHCA; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1
6464
P29353
产品应用
WB: 1:500-1:1000 IHC: 1:50-1:100
Calculated MW:63 kDa;Observed MW: 46,52,66 kDa
研究背景
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals.
研究领域
Neuroscience
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