产品概述
KIF5B (9K4) Rabbit Monoclonal Antibody
Rabbit Monoclonal Antibody
Rabbit
WB,IHC-P,ICC/IF,IP,IF-P
Human,Mouse,Rat
产品性能
Unconjugated
Unmodified
IgG
Monoclonal
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Affinity purification
免疫原
KIF5B
KIF5B; Kinesin1; KINH; KNS; KNS1; UKHC;
3799
P33176
产品应用
WB 1:1000-1:5000, IHC-P/IF-P 1:20-1:100, ICC/IF 1:20-1:100, IP 1:20-1:50
110kDa
研究背景
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2- dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571).
研究领域
武汉恩玑生命科技有限公司
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