产品概述
TPH1 (16G2) Rabbit Monoclonal Antibody
Rabbit Monoclonal Antibody
Rabbit
WB,IHC-P
Human,Mouse
产品性能
Unconjugated
Unmodified
IgG
Monoclonal
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Affinity purification
免疫原
TPH1
TPH1;MGC119994;TPRH;TRPH;Tryptophan 5-hydroxylase 1; Tryptophan Hydroxylase;
7166
P17752
产品应用
WB 1:1000, IHC-P/IF-P 1:200-1:2000
51kDa
研究背景
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin by converting tryptophan to 5-hydroxy-L-tryptophan. Two isoforms of TPH exist: TPH-1 is mainly expressed in the periphery, whereas the expression of TPH-2 is restricted to neuronal cells and the central nervous system. Most of the serotonin found throughout the body is synthesized by TPH-1 in enterochromaffin cells of the gastrointestinal tract. Targeted disruption of the tph1 gene results in low levels of circulating and tissue serotonin. Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate- determining step of serotonin biosynthesis.
研究领域
武汉恩玑生命科技有限公司
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