产品概述
VAMP2 (3Z10) Rabbit Monoclonal Antibody
Rabbit Monoclonal Antibody
Rabbit
WB,ICC/IF,FC,IP
Human,Mouse,Rat
产品性能
Unconjugated
Unmodified
IgG
Monoclonal
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Affinity purification
免疫原
VAMP2
RATVAMPB; RATVAMPIR; SYB2; Synaptobrevin 2; Vamp2l; Vesicle-associated membrane protein 2 (synaptobrevin 2);
6844
P63027
产品应用
WB 1:2000-1:10000, ICC/IF 1:50, FCM 1:20, IP 1:20
13kDa
研究背景
The SNARE complex is involved in vesicular transport and membrane fusion, a process regulated by calcium. In neurons, VAMP2 is predominantly inserted in presynaptic vesicle membranes. Assembly of VAMP2 with the plasma membrane SNAREs syntaxin 1 and SNAP25 is a key event necessary for membrane fusion and neurotransmitter release. Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.
研究领域
武汉恩玑生命科技有限公司
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