产品概述
β Catenin (Phospho Thr41/Ser45) Rabbit Monoclonal antibody
Rabbit Monoclonal antibody
Rabbit
WB,IF,IP,ELISA
Human,Mouse,Rat,
产品性能
Phospho
Phosphorylated
IgG,Kappa
Monoclonal
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Protein A
免疫原
CTNNB1 CTNNB OK/SW-cl.35 PRO2286
CTNNB1;CTNNB;OK/SW-cl.35;Catenin beta-1;Beta-catenin
1499
P35222
产品应用
WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
Calculated MW:86kD;Observed MW:92kD
研究背景
Cell localization:Membrane, Cytoplasm.The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016],
研究领域
武汉恩玑生命科技有限公司
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