产品概述
FAM111A Rabbit Monoclonal antibody
Rabbit Monoclonal antibody
Rabbit
WB,IHC,IF,ICC
Human
产品性能
Unconjugated
Unmodified
IgG,Kappa
Monoclonal
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Protein A
免疫原
FAM111A;KIAA1895
FAM111A;KIAA1895;Serine protease FAM111A;
63901
Q96PZ2
产品应用
WB 1:1000-5000;IHC 1:100-300;ICC/IF 1:100-300
Calculated MW:;Observed MW:67kD
研究背景
Cell localization:Nucleus. Chromosome. Cytoplasm. Note=Mainly localizes to nucleus: colocalizes with PCNA on replication sites...The protein encoded by this gene is cell-cycle regulated, and has nuclear localization. The C-terminal half of the protein shares homology with trypsin-like peptidases and it contains a PCNA-interacting peptide (PIP) box, that is necessary for its co-localization with proliferating cell nuclear antigen (PCNA). Reduced expression of this gene resulted in DNA replication defects, consistent with the demonstrated role for this gene in Simian Virus 40 (SV40) viral replication. Mutations in this gene have been associated with Kenny-Caffey syndrome (KCS) type 2 and the more severe osteocraniostenosis (OCS, also known as Gracile Bone Dysplasia), both characterized by short stature, hypoparathyroidism, bone development abnormalities, and hypocalcemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],
研究领域
武汉恩玑生命科技有限公司
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