产品概述
KMT6 Rabbit Polyclonal Antibody
Rabbit Polyclonal Antibody
Rabbit
WB,IHC-P,ICC/IF,FC
Human,Mouse,Rat
产品性能
Unconjugated
Unmodified
IgG
Polyclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Affinity Chromatography
免疫原
EZH2
WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A; EZH2
2146
Q15910
产品应用
WB: 1:500-1:1000 IHC: 1:50-1:100 IF: 1:50-1:200 FC: 1:50-1:100
Calculated MW: 85 kDa; Observed MW: 98 kDa
研究背景
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
研究领域
Epigenetics and Nuclear Signaling
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