产品概述
ADAM10 Rabbit Polyclonal Antibody
Rabbit Polyclonal Antibody
Rabbit
WB,IP
Human
产品性能
Unconjugated
Unmodified
IgG
Polyclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Affinity Purification
免疫原
ADAM10
CDw156; CD156c; ADAM10; KUZ; MADM
102
O14672
产品应用
WB: 1:500-1:1000 IP: 1:20
Calculated MW: 84 kDa; Observed MW: 90,68 kDa
研究背景
The ADAM10 prodomain acts as a chaperone that stabilizes mature ADAM protein folding, and prevents target-protein shedding through inhibition of ADAM10 proteinase activity. Mature ADAM10 is the major α-secretase responsible for cleavage of Notch, APP, cadherins, and prion protein. The ADAM10 protein cleaves receptor tyrosine kinases and their associated ligands and displays a wide range of regulatory functions across related signaling pathways.
研究领域
Cell Biology
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