产品概述
Phospho-Raf1 (Ser259) Rabbit Polyclonal Antibody
Rabbit Polyclonal Antibody
Rabbit
WB,IHC-P
Human,Mouse,Rat
产品性能
Unconjugated
Phosphorylated
IgG
Polyclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Affinity Chromatography
免疫原
RAF1
RAF1; RAF; RAF proto-oncogene serine/threonine-protein kinase; Proto-oncogene c-RAF; cRaf; Raf-1
5894
P04049
产品应用
WB: 1:500-1:1000 IHC: 1:50-1:100
Calculated MW: 73 kDa; Observed MW: 73 kDa
研究背景
Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2.
研究领域
Signal Transduction
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