产品概述
Cleaved-Caspase 6 p18 Rabbit Polyclonal Antibody
Rabbit Polyclonal Antibody
Rabbit
WB,IHC-P,ELISA
Human,Rat
产品性能
Unconjugated
Cleaved
IgG
Polyclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Chromatography
免疫原
CASP6
CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2
839
P55212
产品应用
WB: 1:500-1:1000 IHC: 1:50-1:100 ELISA: 1:10000
Calculated MW: 33 kDa; Observed MW: 20,35 kDa
研究背景
Caspase-6 (Mch2) is one of the major executioner caspases functioning in cellular apoptotic processes. Upon apoptotic stimulation, initiator caspases such as caspase-9 are cleaved and activated. The activated upstream caspases further process downstream executioner caspases, such as caspase-3 and caspase-6, by cleaving them into large and small subunits, thereby initiating a caspase cascade leading to apoptosis. One of the major targets for caspase-6 is the membrane associated protein lamin A.
研究领域
Cell Biology
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