产品概述
Cleaved-Caspase 4/5 p20 Rabbit Polyclonal Antibody
Rabbit Polyclonal Antibody
Rabbit
WB,ELISA
Human
产品性能
Unconjugated
Cleaved
IgG
Polyclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Chromatography
免疫原
CASP4
TX; Mih1; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II
837/838
P49662/P51878
产品应用
WB: 1:500-1:1000 ELISA: 1:10000
Calculated MW: 43 kDa; Observed MW: 47,22 kDa
研究背景
CASP4 (caspase 4) encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, caspase 4 induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
研究领域
Cell Biology
武汉恩玑生命科技有限公司
联系商家时请提及chemicalbook,有助于交易顺利完成!
在线客服