产品概述
Estrogen Receptor alpha Rabbit Polyclonal Antibody
Rabbit Polyclonal Antibody
Rabbit
WB,IHC-P,FC,IP,ChIP
Human
产品性能
Unconjugated
Unmodified
IgG
Polyclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Affinity Purification
免疫原
ESR1
ESR1; Era; Eralpha; Estrogen receptor; Estradiol receptor; ER-alpha; Estrogen receptor 1; NR3A1; ER; ESR; ESRA; Estrogen receptor alpha
2099
P03372
产品应用
WB: 1:500-1:1000 IHC: 1:50-1:100 IP: 1:20 FC: 1:50-1:100 ChIP: 1:20
Calculated MW: 66 kDa; Observed MW: 66 kDa
研究背景
ER (estrogen receptor 1) a member of the steroid receptor superfamily, contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ER regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylation provides an important mechanism to regulate ER activity. ER is phosphorylated on multiple sites.
研究领域
Signal Transduction
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