产品概述
SQSTM1/p62 Rabbit Polyclonal Antibody
Rabbit Polyclonal Antibody
Rabbit
WB,ICC/IF,FC
Human,Mouse
产品性能
Unconjugated
Unmodified
IgG
Polyclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Affinity Purification
免疫原
SQSTM1
p60; p62; A170; DMRV; OSIL; PDB3; ZIP3; p62B; NADGP; FTDALS3
8878
Q13501
产品应用
WB: 1:500-1:1000 IF: 1:50-1:200 FC: 1:50-1:100
Calculated MW: 48 kDa; Observed MW: 62 kDa
研究背景
Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1.
研究领域
Signal Transduction
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