产品概述
产品名称(Product Name) | NMDAε2 (phospho Tyr1336) Rabbit Polyclonal Antibody |
描述(Description) | Rabbit Polyclonal Antibody |
宿主(Host) | Rabbit |
应用(Application) | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA |
种属反应性(Reactivity) | Human,Mouse,Rat |
产品性能
偶联物(Conjugation) | Unconjugated |
修饰(Modification) | Phospho Antibody |
同种型(Isotype) | IgG |
克隆(Clonality) | Polyclonal |
形式(Form) | Liquid |
存放说明(Storage) | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
储存溶液(Buffer) | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N. |
纯化方式(Purification) | Affinity purification |
免疫原
基因名(Gene Name) | GRIN2B |
别名(Alternative Names) | GRIN2B; NMDAR2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; N-methyl-D-aspartate receptor subunit 3; NR3; hNR3 |
基因ID(Gene ID) | 2904 |
蛋白ID(SwissProt ID) | Q13224 |
产品应用
稀释比(Dilution Ratio) | WB 1:500-1:2000, IHC-P 1:100-1:300, ELISA 1:10000, IF-P/IF-F/ICC/IF 1:50-200 |
蛋白分子量(Molecular Weight) | 150kDa |
研究背景
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008],function:NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4. Interacts with HIP1 (By similarity). Interacts with MAGI3.,tissue specificity:Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.,
研究领域
Neuroactive ligand-receptor interaction;Long-term potentiation;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Huntington's disease;Systemic lupus erythematosus;
关键字: GRIN2B;NMDAε2;(phospho;Tyr1336);Rabbit;Polyclonal;Antibody;一抗
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