产品概述
GRK2 (Phospho-Tyr86) Rabbit Polyclonal Antibody
Rabbit Polyclonal Antibody
Rabbit
IHC-P,IF-P,IF-F,ICC/IF,WB
Human,Mouse,Rat
产品性能
Unconjugated
Phospho Antibody
IgG
Polyclonal
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Affinity purification
免疫原
ADRBK1 BARK BARK1 GRK2
Beta-adrenergic receptor kinase 1 (Beta-ARK-1;EC 2.7.11.15;G-protein coupled receptor kinase 2)
156
P25098
产品应用
IHC-P 1:50-200, WB 1:500-2000, IF-P/IF-F/ICC/IF 1:50-200
75kDa
研究背景
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008],catalytic activity:ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them.,online information:Beta adrenergic receptor kinase entry,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,subunit:Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5.,tissue specificity:Expressed in peripheral blood leukocytes.,
研究领域
武汉恩玑生命科技有限公司
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