产品概述
XRCC4 (7C10) Mouse Monoclonal Antibody
Mouse Monoclonal Antibody
Mouse
WB,IHC-F,IHC-P,ICC/IF,IP
Human,Mouse,Rat
产品性能
Unconjugated
Unmodified
IgG1
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Purification
免疫原
XRCC4
X ray repair cross complementing protein 4; DNA repair protein XRCC4; DNA double strand break repair
7518
Q13426
产品应用
WB: 1:500-1:1000 IHC: 1:50-1:100 IF: 1:50-1:200 IP: 1:20
Calculated MW: 38 kDa; Observed MW: 38-45 kDa
研究背景
Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
研究领域
Epigenetics and Nuclear Signaling
武汉恩玑生命科技有限公司
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