产品概述
产品名称(Product Name) | CD269 Rabbit Polyclonal Antibody |
描述(Description) | Rabbit Polyclonal Antibody |
宿主(Host) | Rabbit |
应用(Application) | WB,ELISA |
种属反应性(Reactivity) | Human,Rat,Mouse |
产品性能
偶联物(Conjugation) | Unconjugated |
修饰(Modification) | Unmodified |
同种型(Isotype) | IgG |
克隆(Clonality) | Polyclonal |
形式(Form) | Liquid |
存放说明(Storage) | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
储存溶液(Buffer) | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N. |
纯化方式(Purification) | Affinity purification |
免疫原
基因名(Gene Name) | TNFRSF17 |
别名(Alternative Names) | TNFRSF17; BCM; BCMA; Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269 |
基因ID(Gene ID) | 608 |
蛋白ID(SwissProt ID) | Q02223 |
产品应用
稀释比(Dilution Ratio) | WB 1:500-1:2000, ELISA 1:10000.Not yet tested in other applications. |
蛋白分子量(Molecular Weight) | 20kDa |
研究背景
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008],disease:A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.,function:Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.,similarity:Contains 1 TNFR-Cys repeat.,subcellular location:Perinuclear Golgi-like structures.,subunit:Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.,tissue specificity:Expressed in mature B-cells, but not in T-cells or monocytes.,
研究领域
Cytokine-cytokine receptor interaction;Intestinal immune network for IgA production;
关键字: TNFRSF17;CD269;Rabbit;Polyclonal;Antibody;一抗
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