产品概述
| 产品名称（Product Name） | IFI-16 Rabbit Polyclonal Antibody |
| 描述（Description） | Rabbit Polyclonal Antibody |
| 宿主（Host） | Rabbit |
| 应用（Application） | WB,ELISA |
| 种属反应性（Reactivity） | Human,Rat,Mouse |
产品性能
| 偶联物（Conjugation） | Unconjugated |
| 修饰（Modification） | Unmodified |
| 同种型（Isotype） | IgG |
| 克隆（Clonality） | Polyclonal |
| 形式（Form） | Liquid |
| 存放说明（Storage） | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 储存溶液（Buffer） | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N. |
| 纯化方式（Purification） | Affinity purification |
免疫原
| 基因名（Gene Name） | IFI16 |
| 别名（Alternative Names） | IFI16; IFNGIP1; Gamma-interferon-inducible protein 16; Ifi-16; Interferon-inducible myeloid differentiation transcriptional activator |
| 基因ID（Gene ID） | 3428 |
| 蛋白ID（SwissProt ID） | Q16666 |
产品应用
| 稀释比（Dilution Ratio） | WB 1:500-1:2000, ELISA 1:40000.Not yet tested in other applications. |
| 蛋白分子量（Molecular Weight） | 88kDa |
研究背景
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011],function:May function as a transcriptional repressor. Could have a role in the regulation of hematopoeitic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in the senescence of prostate epithelial cells.,induction:Strongly induced by gamma interferon and, to a lesser extent, by alpha interferon. In HL-60 cells, maximum induction by gamma-interferon occurs within 12 hours whereas, for alpha-interferon, only 10-fold induction was observed after 36 hours. Induced in vitro by dimethylsulfoxide, retinoic acid and 1,25 dihydroxyvitamin D3.,PTM:Isoform 3 seems to show a minor degree of complex carbohydrate addition.,PTM:Phosphorylated on Ser and Thr.,sequence caution:Intron retention.,similarity:Belongs to the HIN-200 family.,similarity:Contains 1 DAPIN domain.,similarity:Contains 2 HIN-200 domains.,subunit:Isoform 1, isoform 2 and isoform 3 can homo- and hetero-dimerize. Binds double-stranded DNA and cell cycle regulatory factors including p53 and the retinoblastoma protein.,tissue specificity:Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prostate, ovary and breast (at protein level).,
研究领域
关键字： IFI16;IFI-16;Rabbit;Polyclonal;Antibody;一抗
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