GW1929

生物活性靶点体外研究体内研究用途与合成方法MSDSGW1929价格(试剂级)上下游产品信息中文名称GW1929中文同义词N-(2-苯甲酰基苯基)-O-[2-(甲基-2-吡啶基氨基)乙基]-L-酪氨酸;GW1929CALBIOCHEM;(S)-2-((2-苯甲酰基苯基)氨基)-3-(4-(2-(甲基(吡啶-2-基)氨基)乙氧基)苯基)丙酸;GW1929,PPARGAMMA激动剂;化合物GW1929,10MMDMSO溶液英文名称GW1929英文同义词GW1929;GW1929HYDRATE;N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosinehydrate;(2S)-2-(2-benzoylanilino)-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]propanoicacid;(S)-2-(2-Benzoylphenylamino)-3-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)propanoicacid;GW1929hydrochloride;N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosinehydrochloride;N-(2-BENZOYLPHENYL)-O-[2-(METHYL-2-PYRIDINYLAMINO)ETHYL]-L-TYROSINECAS号196808-24-9分子式C30H29N3O4分子量495.57EINECS号相关类别细胞周期;小分子;IntracellularreceptorMol文件196808-24-9.mol结构式GW1929性质沸点749.2±60.0°C(Predicted)密度1.264±0.06g/cm3(Predicted)储存条件Desiccateat+4°C溶解度二甲基亚砜：20毫克/毫升酸度系数(pKa)3.91±0.10(Predicted)形态固体颜色粘黄色InChIKeyQTQMRBZOBKYXCG-MHZLTWQESA-NSMILESC(O)(=O)[C@H](CC1=CC=C(OCCN(C)C2=NC=CC=C2)C=C1)NC1=CC=CC=C1C(=O)C1=CC=CC=C1GW1929用途与合成方法生物活性GW1929是有效的PPAR-γ激动剂，对人PPAR-γ的pKi为8.84。对人和鼠的pEC50分别为8.56和8.27。靶点PPAR-γ8.56(pEC50,HumanPPAR-γ)体外研究GW1929isapotentPPAR-γactivator,withpKisof8.84,<5.5,and<6.5forhumanPPAR-γ,PPAR-α,andPPAR-δ,andpEC50sof8.56and8.27forhumanPPAR-γandmurinePPAR-γ,respectively.GW1929(10μM)inhibitsTBBPA-inducedcaspase-3increaseandTBBPA-stimulatedLDHreleaseinneocorticalcellcultures.体内研究GW1929(0.5,1,5mg/kg,p.o.)highlydecreasesnonfastedplasmaglucoselevelsinZuckerdiabeticfatty(ZDF)ratsaftertreatmentfor14days,andpossessesantilipolyticefficacy.GW1929(1,5mg/kg,p.o.)increasesglucose-stimulatedinsulinesecretionofβ-cellinZDFrats.