APC Anti-Mouse/Rat Foxp3 Antibody[FJK-16s],一抗,二抗
APC Anti-Mouse/Rat Foxp3 Antibody[FJK-16s]
| Alternate Names | IPEXJM2ScurfinZinc finger protein JM2, Forkhead box protein P3 |
| Cellular Localization | Nucleus;Cytoplasm |
| Clone No | FJK-16s |
| Isotype | Rat IgG2a, κ |
| Leadtime | 咨询 |
| Background | FOXP3 is a 47 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4<sup>+</sup>/CD25<sup>-</sup> cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. |
| Abbre | Foxp3 |
| Swissprot | Q99JB6 |
| Host | Rat |
| Reactivity | Mouse;Rat |
| Clonality | Monoclonal |
| Isotype Control | APC Rat IgG2a, κ Isotype Control[2A3] |
| Applications | ICFCM |
| Form | Liquid |
| Conjugation | APC |
| Conjugation Information | APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter). |
| Spectrum | |
| Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Expiration Date | 12个月 |
| Shipping | 冰袋 |
| Gene ID | 20371 |
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