Product Name：Fz7-21
CAS No.：2247635-23-8
Synonyms：拮抗剂多肽Fz7-21
Catalog No.：218P101
Brand：Typeptide Biotech（肽研生物）
Description：Fz7-21是一种FZD7（FZD7）受体的肽拮抗剂，由14个氨基酸组成，肽链的两端均被封闭，选择性地与FZD7-CRD亚类结合。人和小鼠FZD7-CRD的EC50值分别为58和34nm。Fz7-21在外源性WNT3A（IC50=100 nM）刺激或转染表达WNT3A或WNT1的HEK293细胞中削弱Wnt/β-catenin信号传导。小鼠β2 1-3nM细胞的稳定化作用。
Fz7-21 is a peptide antagonist of the FZD7 receptor, composed of 14 amino acids with both ends of the peptide chain blocked. It selectively binds to the FZD7-CRD subclass, with EC50 values of 58 nM and 34 nM for human and mouse FZD7-CRD, respectively. Fz7-21 inhibits Wnt/β-catenin signaling in HEK293 cells stimulated by exogenous WNT3A (IC50=100 nM) or transfected to express WNT3A or WNT1. It also stabilizes β-catenin in mouse cells at 1-3 nM concentrations.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | Ac-LPSDDLEFWCHVMY-NH2 |
Sequence(3-letter code) | Ac-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val-Met-Tyr-NH2 |
Peptide Structure | 
|
Molecular Formula | C83H114N18O23S2 |
Molecular Weight | 1796.04 |
订购联系方式：
南京肽研生物生物科技有限公司
手机号：19961912513(微信同号)
QQ: 2178255659
邮箱：sales@typeptide.com
联系人：顾经理
申明：本产品仅供科研使用，不得用于人体。
关键字： Fz7-21;拮抗剂多肽Fz7-21;2247635-23-8;多肽;多肽合成;
肽研生物坐落于国家级新区南京江北新区新材料产业园，是一家专业从事多肽产 品的研发、生产和销售以及多肽技术转让的高新技术企业。公司秉持“诚信、严 谨、务实”的匠人精神，持续投入研发，不断创新，致力于为科研工作者提供丰 富全面的多肽修饰类型和优质的产品。