Product Name：Nesiritide Acetate （BNP-32）
CAS No.：114471-18-0；124584-08-3
Synonyms：奈西立肽；BNP (1-32), HUMAN；brain natriuretic peptide-32
Catalog No.：177P19
Brand：Typeptide Biotech（肽研生物）
Description：Nesiritide Acetate是一条含有32个氨基酸的多肽，最先是利用重组DNA技术从大肠杆菌(Escherichiacoli)中获得的合成型人类脑利钠肽(brainnatriureticpeptide，BNP)，作用与人类BNP极其相似。Nesiritide中第10和第26个氨基酸(均为半胱氨酸)之间由一个二硫键联接，构成了一个含17个氨基酸的环状结构，所以Nesiritide的稳定性比较好，且在生物体内拥有较长的半衰期。研究表明，以人工合成的Nesiritide为主要原料的药物在心力衰竭，特别是急性心力衰竭的治疗中具有明确的疗效。
Nesiritide Acetate is a peptide containing 32 amino acids, first obtained from Escherichia coli using recombinant DNA technology as a synthetic human brain natriuretic peptide (BNP), which functions very similarly to human BNP. The 10th and 26th amino acids (both cysteine) in Nesritide are connected by a disulfide bond, forming a cyclic structure containing 17 amino acids. Therefore, Nesritide has good stability and a long half-life in organisms. Research has shown that drugs primarily made from artificially synthesized Nesiritide have clear therapeutic effects in the treatment of heart failure, especially acute heart failure.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH (Disulfide bridge Cys10-Cys26) |
Sequence(3-letter code) | H-Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His-OH(Disulfide bridge Cys10-Cys26) |
Peptide Structure | 
|
Molecular Formula | C143H244N50O42S4 |
Molecular Weight | 3464.07 |
订购联系方式：
南京肽研生物生物科技有限公司
手机号：19961912513(微信同号)
QQ: 2178255659
邮箱：sales@typeptide.com
联系人：顾经理
申明：本产品仅供科研使用，不得用于人体。
关键字： 奈西立肽;Nesiritide Acetate （;114471-18-0;多肽;多肽合成;
肽研生物坐落于国家级新区南京江北新区新材料产业园，是一家专业从事多肽产 品的研发、生产和销售以及多肽技术转让的高新技术企业。公司秉持“诚信、严 谨、务实”的匠人精神，持续投入研发，不断创新，致力于为科研工作者提供丰 富全面的多肽修饰类型和优质的产品。