Product Name：B7-33
CAS No.：1818415-56-3
Synonyms：(B7-33)H2；类H2 relaxin多肽；B7-33 relaxin
Catalog No.：218P235
Brand：Typeptide Biotech（肽研生物）
Description：B7-33是一种人工设计的类似于H2 relaxin的多肽，使一条由27个氨基酸组成的多肽。B7-33通过优先与磷酸化丝裂原活化蛋白激酶胞外信号调节激酶，从而激活松弛素肽受体1的信号传导。在动物模型实验中可以得出B7-33可减轻心肌细胞死亡和内质网应激，保护心脏功能，对小鼠急性心肌损伤具有保护作用。同时B7-33在体外成纤维细胞、大鼠和小鼠体内纤维化模型中被证明能特异性结合松弛素受体RXFP1，并优先激活与抗纤维化作用相关的通路，而无副作用。
B7-33 is an artificially designed peptide similar to H2 relaxin, consisting of a 27 amino acid peptide. B7-33 activates the signal transduction of relaxin peptide receptor 1 by preferentially modulating kinase extracellular signaling with phosphorylated mitogen activated protein kinase. In animal model experiments, it can be concluded that B7-33 can alleviate myocardial cell death and endoplasmic reticulum stress, protect cardiac function, and have a protective effect on acute myocardial injury in mice. Meanwhile, B7-33 has been shown to specifically bind to the relaxin receptor RXFP1 in vitro fibroblast, rat, and mouse fibrosis models, and preferentially activate pathways associated with anti fibrotic effects without any side effects.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | VIKLSGRELVRAQIAISGMSTWSKRSL-NH2 |
Sequence(3-letter code) | H-Val-Ile-Lys-Leu-Ser-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Ser-Gly-Met-Ser-Thr-Trp-Ser-Lys-Arg-Ser-Leu-NH2 |
Peptide Structure | 
|
Molecular Formula | C131H228N40O37S1 |
Molecular Weight | 2987.75 |
订购联系方式：
南京肽研生物生物科技有限公司
手机号：19961912513(微信同号)
QQ: 2178255659
邮箱：sales@typeptide.com
联系人：顾经理
申明：本产品仅供科研使用，不得用于人体。
关键字： B7-33;类H2 relaxin多肽；B7-33 ;1818415-56-3;多肽;多肽合成;
肽研生物坐落于国家级新区南京江北新区新材料产业园，是一家专业从事多肽产 品的研发、生产和销售以及多肽技术转让的高新技术企业。公司秉持“诚信、严 谨、务实”的匠人精神，持续投入研发，不断创新，致力于为科研工作者提供丰 富全面的多肽修饰类型和优质的产品。