(Namilumab)Biosimilar Reference Antibody-GS40455 新品

货号：GS40455

Namilumab (also known as MT‑203) is a fully human monoclonal antibody that targets and neutralizes granulocyte‑macrophage colony‑stimulating factor (GM‑CSF), a pro‑inflammatory cytokine. By binding to GM‑CSF with high affinity, it prevents the cytokine from interacting with its receptor (GM‑CSFR) on myeloid cells, thereby inhibiting downstream signaling pathways (e.g., JAK/STAT, MAPK) that drive inflammation and tissue damage. It has been investigated as a potential therapy for autoimmune and inflammatory diseases characterized by excessive GM‑CSF activity, including rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA).