(Negalstobart)Biosimilar Reference Antibody-GS40465

货号：GS40465

Negalstobart is a human IgG4‑kappa monoclonal antibody that specifically targets lymphocyte activation gene 3 (LAG‑3, CD223), an inhibitory immune checkpoint receptor. As an IgG4 isotype, it is engineered to minimize effector functions (e.g., antibody‑dependent cellular cytotoxicity) and focus on checkpoint blockade. By binding to LAG‑3, it blocks the interaction between LAG‑3 and its major ligand major histocompatibility complex class II (MHC‑II), thereby reversing LAG‑3‑mediated suppression of T‑cell activation, proliferation, and cytokine production.