货号:GS40558
Ponsegromab (PF-06946860) is a humanized IgG1 monoclonal antibody designed to selectively neutralize Growth Differentiation Factor 15 (GDF15), a key signaling protein associated with cachexia and metabolic dysfunction. By binding to GDF15, it blocks its interaction with the GFRAL receptor, thereby inhibiting pathways that lead to appetite suppression and weight loss. It is primarily investigated for treating conditions like cancer-associated cachexia.
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