(Cobolimab)Biosimilar Reference Antibody-GS40141 新品

货号：GS40141

Cobolimab is an investigational humanized IgG4 monoclonal antibody targeting the immune checkpoint receptor TIM-3 (T-cell immunoglobulin and mucin domain-containing protein 3). It is designed to enhance anti-tumor immunity by blocking this inhibitory pathway, which is often upregulated in exhausted T cells within the tumor microenvironment. With a potent mechanism of action that involves mediating the internalization of TIM-3 (with an IC₅₀ of 0.4464 nM), it represents a promising therapeutic strategy, particularly for solid tumors like non-small cell lung cancer (NSCLC), where it is being evaluated in clinical studies.