货号:GS40604
Revdofilimab (ABBV-368) is a human IgG1 agonistic monoclonal antibody targeting OX40 (CD134), a co-stimulatory receptor on T cells. By binding and activating OX40, it enhances T cell proliferation, survival, and effector function, while reducing regulatory T cell suppression, thereby promoting anti-tumor immunity. It is being evaluated in clinical trials for advanced solid tumors and hematologic malignancies, often in combination with other immunotherapies.
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