(Lodapolimab)Biosimilar Reference Antibody-GS40396

货号：GS40396

Lodapolimab is a human immunoglobulin G1 lambda (IgG1-λ) monoclonal antibody that specifically targets programmed cell death protein 1 (PD-1), an inhibitory immune checkpoint receptor. As a immune checkpoint inhibitor, it functions by binding to PD-1 on the surface of T cells, blocking its interaction with its ligands PD-L1 and PD-L2. This blockade reverses T‑cell exhaustion and restores anti‑tumor immune responses. It is being developed for the treatment of advanced solid tumors, aiming to enhance immune‑mediated tumor clearance.