货号:GS40696
Tamgiblimab (IBI939) is a fully human IgG4 kappa monoclonal antibody targeting T-cell immunoreceptor with Ig and ITIM domains (TIGIT). It binds to TIGIT on T cells and NK cells, blocking its interaction with ligands such as CD155 (PVR), thereby reversing immune suppression and enhancing anti-tumor immunity. It is being developed for cancer immunotherapy, often in combination with PD-1/PD-L1 inhibitors, in advanced solid tumors.
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