货号:GS40659
Sirexatamab is a humanized IgG4 monoclonal antibody targeting Dickkopf-related protein 1 (DKK1), a secreted inhibitor of the Wnt/β-catenin signaling pathway. By binding to and neutralizing DKK1, it restores Wnt pathway activity, promoting bone formation and potentially modulating tumor microenvironment signaling. It is being developed for the treatment of bone metastatic cancers (e.g., prostate, breast cancer) and osteolytic bone diseases.
武汉迈思生物科技有限公司
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