表面活性剂 SURFACTIN

生物活性Surfactin是一种环状脂肽生物表面活性剂，可介导单价和二价阳离子(如钙离子)穿过脂质双层膜的通量。Surfactin可以作为抗微生物佐剂，具有抗菌，抗真菌，抗支原体和溶血作用。Surfactin还对多种包膜病毒具有抗病毒活性。靶点HSV-1HSV-2体外研究SurfactincanincreasetheactivityofNSC277174againstavianpathogenicEscherichiacoli(APEC)invitrowithantimicrobialassayssuchasminimuminhibitoryconcentrations(MIC)andfractionalinhibitoryconcentration(FIC).ForAPECO78strain,theMICofNSC277174andSurfactinare1000ug/mland>1mg/ml,respectively.体内研究Inthemodelofchickinfection(inoculationofE.coli),SurfactinexertsadjuvanteffectswithNSC277174againstAPECbyloweringthenumericalvalueofmortalityandliverbacterialloads,andregulatingtheexpressionofinflammatorycytokinesetal.SurfactincanactasanovelantimicrobialadjuvantwithNSC277174againstAEPCinfectioninchicken.