HIF-1 alpha, Human, 重组蛋白 (His),HIF-1 alpha Protein, Human, Recombinant (His)

HIF-1 alpha, Human, 重组蛋白 (His)|TMPY-01709|TargetMol

价格	￥493
包装	5μg

最小起订量	5μg
发货地	上海
更新日期	2026-05-08

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产品详情

中文名称:HIF-1 alpha, Human, 重组蛋白 (His)	英文名称:HIF-1 alpha Protein, Human, Recombinant (His)
品牌: TargetMol	产地: 美国
保存条件: Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months	产品类别: 抑制剂
种属: Human	表达系统: E. coli
蛋白长度: A DNA sequence encoding the human HIF1A isoform 1 (Q16665-1) N-terminal segment (Arg 575-Asn 826) was expressed, with a polyhistide tag at the N-terminus. Predicted N terminal: Met	标签: N-His
货号: T011\|TMPY-01709

Product Introduction

Bioactivity

名称	HIF-1 alpha Protein, Human, Recombinant (His)
描述	HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). HIF-1 alpha is expressed in most tissues with the highest levels in the kidney and heart. It is overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors. HIF-1 alpha functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, it activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF1A plays an essential role in embryonic vascularization, tumor angiogenesis, and the pathophysiology of ischemic disease. HIF-1 alpha binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires the recruitment of transcriptional coactivators such as CREBPB and EP300.
存储条件	Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months
关键字	PASD-8 \| PASD 8 \| MOP-1 \| MOP 1 \| hypoxia inducible factor 1, α subunit \| hypoxia inducible factor 1, alpha subunit \| hypoxia inducible factor 1, a subunit \| hif1α \| HIF-1 \| HIF 1 \| basic helix-loop-helix transcription factor

关键字： PASD8;MOP1;hypoxia inducible factor 1, α subunit (basic helix-loop-helix transcription factor);hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor);HIF1-α;HIF-1α;HIF1-ALPHA;HIF-1alpha;HIF-1A;HIF-1 α;HIF1;bHLHe78;TargetMol

公司简介

成立日期	2013-04-18 （14年）	注册资本	589.8595万人民币
员工人数	100-500人	年营业额	￥ 1亿以上
主营行业	天然产物,生物化工,化学试剂,生物技术服务	经营模式	贸易,工厂,试剂,定制,服务

TargetMol 中国（陶术生物）

VIP 1年

公司成立：14年
注册资本：589.8595万人民币
企业类型：股份有限公司(非上市、自然人投资或控股)
主营产品：活性分子、生化试剂、天然产物、重组蛋白、抗体相关、试剂盒、药物筛选化合物库、技术服务
公司地址：静安区江场三路238号8楼

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HIF-1 alpha, Human, 重组蛋白 (His)|TMPY-01709|TargetMol相关厂家报价

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重组Human B2M 蛋白, C-His	￥1788	VIP2年	普健生物（武汉）科技有限公司	2026-08-07
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