Product Name：BMP2-derived peptide
CAS No.：836606-84-9
Synonyms：受体配体多肽BMP2-derived peptide
Catalog No.：220P391
Brand：Typeptide Biotech（肽研生物）
Description：BMP2-derived peptide 是一种成骨诱导剂及 BMP 受体配体多肽，是由20各氨基酸组成的多肽。BMP2-derived peptide 通过与细胞表面的 BMP 受体结合形成复合物，激活下游 Smad 信号通路并调控成骨转录因子的表达。BMP2-derived peptide 能有效促进骨髓间充质干细胞的黏附、增殖、成骨分化及矿化，显著上调 OCN、Runx2 和 Ⅰ 型胶原的 mRNA 水平，并提升碱性磷酸酶活性与钙沉积量。BMP2-derived peptide 可诱导成骨细胞分化与异位骨再生，改善颅骨骨缺损修复。BMP2-derived peptide 同时能增强介孔二氧化硅纳米颗粒的细胞相容性，与 Dexamethasone (HY-14648) 协同提升成骨活性，并可从 CS-P24/HA 支架中实现长达 90 天的缓释，是骨缺损修复研究的重要工具。
BMP2 derived peptide is an osteogenic inducer and BMP receptor ligand peptide, composed of 20 amino acids. BMP2 derived peptide forms a complex by binding to BMP receptors on the cell surface, activating downstream Smad signaling pathways and regulating the expression of osteogenic transcription factors. BMP2 derived peptide can effectively promote the adhesion, proliferation, osteogenic differentiation, and mineralization of bone marrow mesenchymal stem cells, significantly upregulate the mRNA levels of OCN, Runx2, and type I collagen, and enhance alkaline phosphatase activity and calcium deposition. BMP2 derived peptide can induce osteoblast differentiation and ectopic bone regeneration, improving skull bone defect repair. BMP2 derived peptide can enhance the cellular compatibility of mesoporous silica nanoparticles, synergistically improve osteogenic activity with Dexamethasone (HY-14648), and achieve sustained release for up to 90 days from CS-P24/HA scaffolds, making it an important tool for bone defect repair research.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | KIPKASSVPTELSAISTLYL-NH2 |
Sequence(3-letter code) | H-Lys-Ile-Pro-Lys-Ala-Ser-Ser-Val-Pro-Thr-Glu-Leu-Ser-Ala-Ile-Ser-Thr-Leu-Tyr-Leu-NH2 |
Peptide Structure | 
|
Molecular Formula | C97H165N23O29 |
Molecular Weight | 2117.48 |
订购联系方式：
南京肽研生物生物科技有限公司
手机号：19961912513(微信同号)
QQ: 2178255659
邮箱：sales@typeptide.com
联系人：顾经理
申明：本产品仅供科研使用，不得用于人体。
关键字： BMP2-derived peptide;受体配体多肽BMP2-derived p;836606-84-9;多肽;多肽合成;
肽研生物坐落于国家级新区南京江北新区新材料产业园，是一家专业从事多肽产 品的研发、生产和销售以及多肽技术转让的高新技术企业。公司秉持“诚信、严 谨、务实”的匠人精神，持续投入研发，不断创新，致力于为科研工作者提供丰 富全面的多肽修饰类型和优质的产品。