933A 99% 90212-84-3 Antitumor and anti-inflammatory

1、Product introduction

933A belongs to the class of cross derivatives of hydroxamic acid and sulfoxides, and is commonly modified in medicinal chemistry as the scaffold for inhibitors of matrix metalloproteinases (MMPs) or histone deacetylases (HDACs). Its most significant application lies in serving as a lead compound for research and development of antitumor or anti-inflammatory drugs. The mechanism involves competitive inhibition of MMP activity by mimicking substrates, thereby blocking tumor cell invasion and metastasis or suppressing excessive inflammatory responses. The hydroxamic acid structure also constitutes the core scaffold of HDAC inhibitors (e.g., the well-known SAHA, fulinotamide). Consequently, this compound provides a valuable structural basis for designing multi-target drugs that inhibit both MMPs and HDACs.

2、Feature

1) Physical properties: appears as white or off-white crystalline powder. Due to the presence of polar groups, it exhibits good solubility in dimethyl sulfoxide (DMSO) or alcohols, but low solubility in non-polar organic solvents. Storage under low temperature, dry conditions, and protected from light is generally recommended to prevent oxidation or degradation of the hydroxamic acid groups.

(2) Stability: This compound may be sensitive to metal ions (particularly iron or zinc ions), and complexation reactions upon contact with metals may lead to structural alterations.

3、Applications

1) Chemical tools: In biochemistry, they can be used to study the interaction mechanisms between enzymes and substrates or serve as positive controls to verify the reliability of enzyme activity detection systems;

2) Antitumor : The hydroxamic acid group can chelate zinc ions at the active site of MMPs, rendering them inactive and thereby inhibiting their invasiveness and metastasis;

3) Anti-inflammatory: They prevent immune cells from readily crossing vascular walls and the extracellular matrix (ECM) to reach inflammatory sites and release additional inflammatory mediators, thus controlling excessive inflammation spread.

【关于我们】

苏州麦轮生物科技有限公司是一家创新的生命科学补充剂、定制合成和制造服务公司。我们是FDA 注册制造商，以稳定的质量和可持续的增长确保人类健康。我们生产和采购各种营养补充剂，保健品原料。

在苏州麦轮，为了确保产品质量，制造过程按照预定的流程和程序在严格的监督下进行。我们确保符合 GMP 标准，产品符合国际质量标准。我们根据 GMP 标准和 ISO 9001:2015 认证记录了所有类型的标准操作程序。我们采用ISO9001-2015质量管理体系和GMP标准，以提高我们产品和服务的国际质量标准。

我们所有的产品都通过了 CP、BP、EP 和 USP 等药典的严格测试。所有商品均为新鲜生产，保质期为2至3年。

我们在苏州工业园区设有中央仓库，以确保严格的QC流程执行。同时我们在美国和欧洲设立了子仓库，以确保产品尽快到达我们的客户手中。

【常见问题解答】

【1】问: 你们的交货时间是多少？

 答: 一般在收到付款后1~5 天。

【2】问: 你们的装运港在哪里？

 答:上海/宁波。

【3】问: 具体包装是什么形式的？

 答: 通常我们的包装是1公斤/袋和25公斤/桶。当然，如果您有特殊要求，我们也会根据您的要求进行包装。

【4】问: 贵公司能够接受定制并满足客户特定的规格要求吗？

答：是的，我们可以。

【5】问: 贵公司能提供样品吗？

  答: 是的，我们可以，具体的样品信息请通过电话与我们联系。