COX-2, Human, 重组蛋白 (His)|TMPY-01736|TargetMol

价格	￥6530
包装	100μg

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中文名称:COX-2, Human, 重组蛋白 (His)	英文名称:COX-2 Protein, Human, Recombinant (His)
品牌: TargetMol	产地: 美国
保存条件: Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months	纯度规格: 92.10%
产品类别: 抑制剂
种属: Human	表达系统: Baculovirus Insect Cells
蛋白长度: A DNA sequence encoding the human PTGS2 (NP_000954.1) (Met 1-Leu 604) was fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Ala 18	标签: C-His
货号: T011\|TMPY-01736

名称	COX-2 Protein, Human, Recombinant (His)
描述	PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS2 is overexpressed in many cancers. The overexpression of PTGS2 along with increased angiogenesis and GLUT-1 expression is significantly associated with gallbladder carcinomas. Furthermore the product of COX-2, PGH2 is converted by prostaglandin E2 synthase into PGE2, which in turn can stimulate cancer progression. Consequently inhibiting COX-2 may have benefit in the prevention and treatment of these types of cancer. PTGS2 is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. It mediates the formation of prostaglandins from arachidonate and may have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
存储条件	Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months
关键字	PHS2 \| PHS 2 \| PGHS2 \| PGHS 2 \| COX 2

关键字： prostaglandin-endoperoxide synthase 2;PHS-2;PGHS-2;PGG/HS;hCox-2;GRIPGHS;COX-2;COX2;TargetMol

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