PAK-3, Human, 重组蛋白 (His)|TMPY-04397|TargetMol

价格	￥1930
包装	20μg

QQ交谈微信洽谈

产品详情

中文名称:PAK-3, Human, 重组蛋白 (His)	英文名称:PAK-3 Protein, Human, Recombinant (His)
品牌: TargetMol	产地: 美国
保存条件: Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months	产品类别: 抑制剂
货号: TMPY-04397

名称	PAK-3 Protein, Human, Recombinant (His)
描述	PAK3 is a member of PAK proteins, a family of serine/threonine p21-activating kinases, serve as effectors of small Rho GTPases Cdc42 and RAC and have been implicated in a wide range of biological activities. There are six mammalian PAKs which can be divided into two groups: group I PAKs (PAK1-3) and group II PAKs (PAK4-6). Although the two PAK groups are architecturally similar there are differences in their mode of regulation suggesting their cellular functions are likely to be different. Group I p21-activated kinases (PAK1/2/3) is demonstrated as ERK3/ERK4 activation loop kinases. It has been shown that group I PAKs phosphorylate ERK3 and ERK4 on Ser-189 and Ser-186, respectively, both in vitro and in vivo, and that expression of activated Rac1 augments this response. Besides regulation enzymatic activation of ERK3/ERK4, PAKs can also play roles in downstream activation of MAP kinase-activated protein kinase 5 (MK5) in vivo. Thus, the group I PAKs act as upstream activators of ERK3 and ERK4 and unravel a novel PAK-ERK3/ERK4-MK5 signaling pathway. In clinical, PAK has been proposed as a potential therapeutic target in schwannomas.
存储条件	Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months
关键字	OPHN-3 \| OPHN 3 \| MRX-47 \| MRX-30 \| MRX 47 \| MRX 30

关键字： PAK3β|||PAK3beta|||p21 protein (Cdc42/Rac)-activated kinase 3|||OPHN3|||MRX47|||MRX30|||hPAK3|||CDKN1A|||bPAK|TargetMol

VIP 1年

进入店铺

询盘

￥9530

询价

￥2380

内容声明:
以上所展示的信息由商家自行提供，内容的真实性、准确性和合法性由发布商家负责。商家发布价格指该商品的参考价格，并非原价，该价格可能随着市场变化，或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格，请咨询商家，以实际成交价格为准。请意识到互联网交易中的风险是客观存在的