Coagulation factor XI/F11 , Human, 重组蛋白 (His),Coagulation factor XI/F11  Protein, Human, Recombinant (His)
  • Coagulation factor XI/F11 , Human, 重组蛋白 (His),Coagulation factor XI/F11  Protein, Human, Recombinant (His)

Coagulation factor XI/F11 , Human, 重组蛋白 (His)|TMPY-01104|TargetMol

价格 4470
包装 50μg
最小起订量 50μg
发货地 上海
更新日期 2026-05-08
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产品详情

中文名称:Coagulation factor XI/F11 , Human, 重组蛋白 (His)英文名称:Coagulation factor XI/F11 Protein, Human, Recombinant (His)
品牌: TargetMol产地: 美国
保存条件: Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months纯度规格: 97.80%
产品类别: 抑制剂
种属: Human表达系统: HEK293 Cells
蛋白长度: A DNA sequence encoding the human F11 (NP_000119.1) precursor (Met 1-Val 625) with a carboxy-terminal polyhistidine tag was expressed. Predicted N terminal: Glu 19标签: C-His
货号: T011|TMPY-01104
2026-05-08 Coagulation factor XI/F11 , Human, 重组蛋白 (His) Coagulation factor XI/F11 Protein, Human, Recombinant (His) 50μg/4470RMB 4470 TargetMol 美国 Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months 97.80% 抑制剂

Product Introduction

Bioactivity

名称Coagulation factor XI/F11 Protein, Human, Recombinant (His)
描述Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease, with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa and then is processed into a disulfide-bond linked homodimer. FXI is a homodimer, with each subunit containing four apple domains and a protease domain. The apple domains form a disk structure with binding sites for platelets, high molecular weight kininogen, and the substrate factor IX (FIX). FXI is converted to the active protease FXIa by cleavage of the Arg369-Ile370 bond on each subunit. After the activation reaction, Factor XIa is composed of two heavy and two light chains held together by three disulfide bonds. The heavy chains are derived from the amino termini of the zymogen and responsible for the binding of factor XI to high molecular weight kininogen and for the activation of factor IX, while the light chain contains the catalytic portion of the enzyme and is homologous to the trypsin family of serine proteases. FXI deficiency is a disorder characterized by a mild or no bleeding tendency. Severe FXI deficiency is an injury-related bleeding disorder common in Ashkenazi Jews and rare worldwide.
存储条件Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
关键字: FXI;coagulation factor XI;coagulation factor 11;TargetMol

公司简介

成立日期 2013-04-18 (14年) 注册资本 589.8595万人民币
员工人数 100-500人 年营业额 ¥ 1亿以上
主营行业 天然产物,生物化工,化学试剂,生物技术服务 经营模式 贸易,工厂,试剂,定制,服务
  • TargetMol 中国(陶术生物)
VIP 1年
  • 公司成立:14年
  • 注册资本:589.8595万人民币
  • 企业类型:股份有限公司(非上市、自然人投资或控股)
  • 主营产品:活性分子、生化试剂、天然产物、重组蛋白、抗体相关、试剂盒、药物筛选化合物库、技术服务
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