TRIM21, Mouse, 重组蛋白 (His),TRIM21 Protein, Mouse, Recombinant (His)

TRIM21, Mouse, 重组蛋白 (His)|TMPH-02633|TargetMol

价格	￥21300
包装	1mg

最小起订量	1mg
发货地	上海
更新日期	2026-05-08

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产品详情

中文名称:TRIM21, Mouse, 重组蛋白 (His)	英文名称:TRIM21 Protein, Mouse, Recombinant (His)
品牌: TargetMol	产地: 美国
保存条件: Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months	产品类别: 抑制剂
种属: Mouse	表达系统: Baculovirus Insect Cells
蛋白长度: 1-470 aa	标签: N-10xHis
货号: T011\|TMPH-02633

Product Introduction

Bioactivity

名称	TRIM21 Protein, Mouse, Recombinant (His)
描述	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses. Represses the innate antiviral response by facilitating the formation of the NMI-IFI35 complex through 'Lys-63'-linked ubiquitination of NMI.
存储条件	Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months
关键字	Trim 21 \| Ssa 1 \| SS-A \| SSA \| Ro 52 \| 52kDa Ro protein

关键字： Tripartite motif-containing protein 21;Trim21;Ssa1;Sjoegren syndrome type A antigen (SS-A);Ro52;Ro(SS-A);E3 ubiquitin-protein ligase TRIM21;52 kDa Ro protein;52 kDa ribonucleoprotein autoantigen Ro/SS-A;TargetMol

公司简介

成立日期	2013-04-18 （14年）	注册资本	589.8595万人民币
员工人数	100-500人	年营业额	￥ 1亿以上
主营行业	天然产物,生物化工,化学试剂,生物技术服务	经营模式	贸易,工厂,试剂,定制,服务

TargetMol 中国（陶术生物）

VIP 1年

公司成立：14年
注册资本：589.8595万人民币
企业类型：股份有限公司(非上市、自然人投资或控股)
主营产品：活性分子、生化试剂、天然产物、重组蛋白、抗体相关、试剂盒、药物筛选化合物库、技术服务
公司地址：静安区江场三路238号8楼

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TRIM21, Mouse, 重组蛋白 (His)|TMPH-02633|TargetMol相关厂家报价

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重组Human B2M 蛋白, C-His	￥1788	VIP2年	普健生物（武汉）科技有限公司	2026-08-07
重组小鼠PZP蛋白 \| Mouse PZP, 1246-1495aa, His-tag, GST-tag	询价	VIP4年	维百奥（北京）生物科技有限公司	2026-07-30
组蛋白H3(H3)重组蛋白	￥2600	VIP5年	上海博尔森生物科技有限公司	2026-08-13

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