SMARCA4, Human, 重组蛋白 (His),SMARCA4 Protein, Human, Recombinant (His)

SMARCA4, Human, 重组蛋白 (His)|TMPH-02217|TargetMol

价格	￥4650
包装	200μg

最小起订量	200μg
发货地	上海
更新日期	2026-05-08

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产品详情

中文名称:SMARCA4, Human, 重组蛋白 (His)	英文名称:SMARCA4 Protein, Human, Recombinant (His)
品牌: TargetMol	产地: 美国
保存条件: Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months Shipping with blue ice/Shipping at ambient temperature.	纯度规格: 90.00%
产品类别: 抑制剂
货号: TMPH-02217

Product Introduction

Bioactivity

名称	SMARCA4 Protein, Human, Recombinant (His)
描述	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2. Binds to RNA in a promiscuous manner. Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities.
存储条件	Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months Shipping with blue ice/Shipping at ambient temperature.
关键字	SNF2-β \| SNF2β \| SNF2L 4 \| SNF2-b \| SMARCA 4 \| Protein BRG1 \| BRG 1 \| BA F190A

关键字： Transcription activator BRG1|||SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4|||SNF2L4|||SNF2-beta|||SNF2B|||SMARCA4|||Protein BRG-1|||Protein brahma homolog 1|||Mitotic growth and transcription activator|||BRG1-associated factor 190A (BAF190A)|||BRG1|||BAF190A|||ATP-dependent helicase SMARCA4|TargetMol

公司简介

成立日期	2013-04-18 （14年）	注册资本	589.8595万人民币
员工人数	100-500人	年营业额	￥ 1亿以上
主营行业	天然产物,生物化工,化学试剂,生物技术服务	经营模式	贸易,工厂,试剂,定制,服务

TargetMol 中国（陶术生物）

VIP 1年

公司成立：14年
注册资本：589.8595万人民币
企业类型：股份有限公司(非上市、自然人投资或控股)
主营产品：活性分子、生化试剂、天然产物、重组蛋白、抗体相关、试剂盒、药物筛选化合物库、技术服务
公司地址：静安区江场三路238号8楼

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询价

SMARCA4, Human, 重组蛋白 (His)|TMPH-02217|TargetMol相关厂家报价

产品名称	价格		公司名称	报价日期
重组Human B2M 蛋白, C-His	￥1788	VIP2年	普健生物（武汉）科技有限公司	2026-05-09
Recombinant Human SMARCA4 Protein	￥1950	VIP4年	上海沪震实业有限公司	2026-05-08
组蛋白H4(H4)重组蛋白	￥2460	VIP7年	上海泽叶生物科技有限公司	2026-05-08

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