| 名称 | PACAP (6-38), human, ovine, rat acetate |
| 描述 | PACAP (6-38), human, ovine, rat acetate is a potent PACAP receptor antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2, respectively. |
| 体外活性 | 通过HPLC分析观察到地塞米松(DEX)可增加多巴胺(DA)含量，并通过MTT测定发现其促进细胞增殖，而这些效应可被PACAP(6-38)在足够浓度下通过阻断PAC1受体而抑制。预处理0.1或1μM的PACAP(6-38) 2小时，显著阻断了1μM DEX所致的DA含量上升。MTT测定结果显示，DEX能增加细胞增殖，而预先孵育PACAP(6-38)也能抑制这一作用。在24小时的实验中，1μM的PACAP(6-38)对DA含量和细胞增殖无影响。然而，0.3μM的PACAP(6-38)已被提及在5天内减少分化的视网膜培养细胞中自发的酪氨酸羟化酶(TH)积累[2]。 |
| 体内活性 | 通过膀胱内给药方式，将PACAP (6-38) (300 nM) 注入NGF-OE小鼠，显著（p≤0.01）延长了排尿间隔时间（增加了2倍）和排尿量（增加了2.5倍）。此外，PACAP (6-38) 的膀胱内注射还降低了NGF-OE小鼠的基线膀胱压力。同样的膀胱内给药方式对于NGF-OE小鼠，PACAP (6-38) (300 nM) 还能显著（p≤0.01）减轻盆腔敏感性，但是对于野生型（WT）小鼠则无影响[3]。 |
| 存储条件 | Store at low temperature,Keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | H2O : 50 mg/mL (12.24 mM), Sonication is recommended.
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| 关键字 | PACAP type I | PACAP , human, ovine, rat Acetate | PACAP (638), human, ovine, rat acetate(143748189 Free base) | PACAP (6 38), human, ovine, rat acetate(143748 18 9 Free base) |
| 相关产品 | PACAP (1-27), human, ovine, rat TFA | PACAP 1-38 acetate | Thielocin B1 | PACAP-38 (31-38), human, mouse, rat acetate | PACAP (1-38), human, ovine, rat TFA | PACAP (1-27), human, ovine, rat acetate | PA-8 | PACAP-38 (16-38), human, mouse, rat | PAC1R antagonist 1 | PACAP (1-38) | PACAP (1-38), human, ovine, rat | VIP(Guinea pig) |
| 相关库 | 多肽分子库 |